How does gonadorelin compare to hCG?

Patients on testosterone who wish to stem or reverse testicular shrinkage may use either gonadorelin or low-dose hCG. Gonadorelin may come with fewer estrogenic effects compared to hCG and is generally considered the drug of choice in younger patients with fertility aspirations.

How does gonadorelin affect semen?

Gonadorelin enhances semen production by increasing total expressible volume. It does appear to impact sperm quality.2